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VANGUARD® PLUS 5 L4 CV

EFFECTIVE AGAINST SERIOUS DISEASE THREATS TO DOGS—CD VIRUS, CAV-1, CAV-2, CPI VIRUS, CPV AND CPV-2C—AND HELPS TO PREVENT LEPTOSPIROSIS AND CANINE CORONAVIRUS INFECTIONS

VANGUARD Plus 5 L4 CV is for vaccination of healthy dogs 6 weeks of age or older as an aid in preventing:

  • Canine distemper caused by canine distemper (CD) virus.

  • Infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1).

  • Respiratory disease caused by canine adenovirus type 2 (CAV-2).

  • Canine parainfluenza caused by canine parainfluenza (CPI) virus.

  • Enteritis caused by canine coronavirus (CCV), canine parvovirus (CPV) and CPV-2c.

  • Leptospirosis caused by Leptospira canicola, L. grippotyphosa, L. icterohaemorrhagiae and L. pomona.

IMPORTANT NOTICE!

Please note that this is a general product information according to US approvals, for specific regulatory information concerning your market please contact Regulatory department email: Regulatory.AffairsMER@zoetis.com

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  • Key benefits
    • Demonstrated performance of the viral antigens based on retrospective serological studies.1
    • VANGUARD Plus 5 L4 CV is a freeze-dried preparation of attenuated strains of CD virus, CAV-2, CPI virus, CPV, and inactivated whole cell cultures of L. canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona. 
    • Leptospira cells are extensively rinsed, resulting in reduced extraneous materials.
    • A microfiltration process helps remove extraneous proteins. 
    • Safety documented by large-scale, multicenter study.
    • Efficacy confirmed against the most common canine Leptospira serovars.
    • Covered by the Companion Animal Immunization Support Guarantee.
  • Dosage And Adminstration

    Directions: Aseptically rehydrate the freeze-dried vaccine (Vanguard Plus 5 L4) with the accompanying vial of adjuvanted liquid vaccine (Vanguard CV), shake well, and administer 1 mL subcutaneously or intramuscularly. Healthy dogs should receive 2 doses administered 3 weeks apart, followed by a single dose of Vanguard CV 3 weeks later. To avoid the potential for maternal antibody interference, dogs vaccinated at less than 9 weeks of age should receive 3 doses of the combination vaccine, each administered 3 weeks apart. Annual revaccination with a single dose is recommended.

    Precautions: Store at 2°-7°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze. Use entire contents when first opened. Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine. Burn containers and all unused contents. Contains gentamicin as preservative. Vaccination of pregnant bitches should be avoided. In case of anaphylaxis, administer epinephrine or equivalent.

    References

    1. Mouzin DE, Lorenzen MJ, Haworth JD, et al. Duration of serologic response to five viral antigens in dogs. J Am Vet Med Assoc 2004; 224: 55-60.