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DOMOSO® SOLUTION

(DIMETHYL SULFOXIDE)

DOMOSO (dimethyl sulfoxide) Solution is recommended as a topical application to reduce acute swelling due to trauma.

DOMOSO (dimethyl sulfoxide) Solution is recommended as a topical application to reduce acute swelling due to trauma.

IMPORTANT NOTICE!

Please note that this is a general product information according to US approvals, for specific regulatory information concerning your market please contact Regulatory department email: Regulatory.AffairsMER@zoetis.com

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  • Equine

    Product description:

    Indications:

    DOMOSO (dimethyl sulfoxide) Solution is recommended as a topical application to reduce acute swelling due to trauma.

    Dosing and Administration:

    DOMOSO Solution is to be administered topically to the skin over the affected area. The spray pump should be initially held approximately 6 inches from the animal and the distance adjusted to provide a uniform coverage of the area. The volume delivered by depressing the spray pump is approximately 1/3 mL. Refer to user precautions below under

    Horses

    Liberal application should be administered two to three times daily. Total daily dosage should not exceed 100 mL. Total duration of therapy should not exceed 30 days.

    PRECAUTIONS AND CONTRAINDICATIONS

    Contact between DOMOSO Solution and the skin should be avoided. Rubber gloves should be worn while applying this drug. Forceps and swabs may be used to facilitate application. If absorbed through the skin, DOMOSO Solution will cause odorous breath and unpleasant mouth taste. Mild sedation or drowsiness, sensations of warmth, burning, irritation, itching and mild erythematous localized or generalized dermatitis have been reported in some persons following exposure to DOMOSO Solution. Treatment of such side effects is symptomatic. Consult a physician immediately if adverse effects appear.

    DOMOSO Solution may mask certain disease signs such as are seen in fractures etc.; this does not obviate the need for specific therapy in such conditions. DOMOSO should not be used directly prior to racing or other physical stress wherein the drug might mask existing pathology, such as a fracture.

    Since DOMOSO Solution effectively alters the biologic membrane, it will in some cases facilitate the systemic absorption of other topically applied drugs and may have a potentiating effect on drugs administered systemically. Therefore, great care should be exercised in use of other drugs at the DOMOSO Solution application site because of the demonstrated - if variable - ability of DMSO to carry other chemicals through the dermis into the general circulation. If other topical medications are indicated they should not be applied until DOMOSO Solution is thoroughly dry. Frequently, due to the heat of resolution, a “smoking” effect following application is noted due to vaporization of the drug.

    DOMOSO Solution should also be judiciously used when administered in conjunction with other pharmaceutical preparations, especially those affecting the cardiovascular and central nervous systems. DMSO may potentiate the activity of atropine, insulin, endogenous steroids and certain other drugs.

    Lowering of the vagal threshold, spontaneous skeletal muscle fasciculation, and increased smooth muscle tone in the stomach following DMSO exposure may be due to cholinesterase inhibition. Therefore, DOMOSO Solution should not be used on dogs, or horses, simultaneously or within a few days before or after treatment with, or exposure to, cholinesterase-inhibiting pesticides or drugs.

    DOMOSO SOLUTION IS RECOMMENDED FOR TOPICAL APPLICATION ONLY. THE APPLICATION OF DOMOSO SOLUTION SHOULD TAKE PLACE ONLY IN WELL VENTILATED QUARTERS. INHALATION OF THE DRUG SHOULD BE AVOIDED. AVOID CONTACT OF THE MEDICATION WITH THE EYES.

    Keep DOMOSO Solution out of the reach of children.

    DO NOT ADMINISTER BY ANY OTHER ROUTE.

    DOMOSO Solution should not be used under occlusive dressings. DOMOSO Solution is contraindicated in horses and dogs intended for breeding purposes.

    DOMOSO Solution is a potent solvent and may have a deleterious effect on fabrics, plastics and other materials. Care should be taken to prevent physical contact with DOMOSO Solution and these materials, either alone or until drying of the treated skin surface has occurred when applied to an animal.

    CAUTION: EXTREMELY HYGROSCOPIC! CLOSE BOTTLE CAP TIGHTLY AFTER USE. AVOID FREEZING. DUE TO THE RAPID PENETRATION ABILITY OF DOMOSO, RUBBER GLOVES SHOULD BE WORN WHEN APPLYING THIS DRUG.

  • Dogs

    Product description:

    Indications:

    DOMOSO (dimethyl sulfoxide) Solution is recommended as a topical application to reduce acute swelling due to trauma.

    Dosing and Administration:

    DOMOSO Solution is to be administered topically to the skin over the affected area. The spray pump should be initially held approximately 6 inches from the animal and the distance adjusted to provide a uniform coverage of the area. The volume delivered by depressing the spray pump is approximately 1/3 mL. Refer to user precautions below under

    Dogs - Liberal application should be administered three to four times daily. Total daily dosage should not exceed 20 mL. Total duration of therapy should not exceed 14 days.

    PRECAUTIONS AND CONTRAINDICATIONS

    Contact between DOMOSO Solution and the skin should be avoided. Rubber gloves should be worn while applying this drug. Forceps and swabs may be used to facilitate application. If absorbed through the skin, DOMOSO Solution will cause odorous breath and unpleasant mouth taste. Mild sedation or drowsiness, sensations of warmth, burning, irritation, itching and mild erythematous localized or generalized dermatitis have been reported in some persons following exposure to DOMOSO Solution. Treatment of such side effects is symptomatic. Consult a physician immediately if adverse effects appear.

    DOMOSO Solution may mask certain disease signs such as are seen in fractures etc.; this does not obviate the need for specific therapy in such conditions. DOMOSO should not be used directly prior to racing or other physical stress wherein the drug might mask existing pathology, such as a fracture.

    Since DOMOSO Solution effectively alters the biologic membrane, it will in some cases facilitate the systemic absorption of other topically applied drugs and may have a potentiating effect on drugs administered systemically. Therefore, great care should be exercised in use of other drugs at the DOMOSO Solution application site because of the demonstrated - if variable - ability of DMSO to carry other chemicals through the dermis into the general circulation. If other topical medications are indicated they should not be applied until DOMOSO Solution is thoroughly dry. Frequently, due to the heat of resolution, a “smoking” effect following application is noted due to vaporization of the drug.

    DOMOSO Solution should also be judiciously used when administered in conjunction with other pharmaceutical preparations, especially those affecting the cardiovascular and central nervous systems. DMSO may potentiate the activity of atropine, insulin, endogenous steroids and certain other drugs.
    Lowering of the vagal threshold, spontaneous skeletal muscle fasciculation, and increased smooth muscle tone in the stomach following DMSO exposure may be due to cholinesterase inhibition. Therefore, DOMOSO Solution should not be used on dogs, or horses, simultaneously or within a few days before or after treatment with, or exposure to, cholinesterase-inhibiting pesticides or drugs.

    DOMOSO SOLUTION IS RECOMMENDED FOR TOPICAL APPLICATION ONLY. THE APPLICATION OF DOMOSO SOLUTION SHOULD TAKE PLACE ONLY IN WELL VENTILATED QUARTERS. INHALATION OF THE DRUG SHOULD BE AVOIDED. AVOID CONTACT OF THE MEDICATION WITH THE EYES.

    Keep DOMOSO Solution out of the reach of children.

    DO NOT ADMINISTER BY ANY OTHER ROUTE.

    DOMOSO Solution should not be used under occlusive dressings. DOMOSO Solution is contraindicated in horses and dogs intended for breeding purposes.

    DOMOSO Solution is a potent solvent and may have a deleterious effect on fabrics, plastics and other materials. Care should be taken to prevent physical contact with DOMOSO Solution and these materials, either alone or until drying of the treated skin surface has occurred when applied to an animal.

    CAUTION: EXTREMELY HYGROSCOPIC! CLOSE BOTTLE CAP TIGHTLY AFTER USE. AVOID FREEZING. DUE TO THE RAPID PENETRATION ABILITY OF DOMOSO, RUBBER GLOVES SHOULD BE WORN WHEN APPLYING THIS DRUG.